Micro
tubules form flexible fibers, which are u
tilized in cell prolifera
tion and differen
tia
tion. Al
though
the flexibili
ty of micro
tubules was shown
to be regula
ted by various micro
tubule-associa
ted pro
teins,
this regula
tion is s
till far from comple
te unders
tanding. Here, we repor
t a new po
ten
tial regula
tor of micro
tubules in mammals. Gcap14 colocalizes wi
th micro
tubules in mammalian cells
transfec
ted wi
th Gcap14 expression vec
tor. Associa
tion of Gcap14 wi
th micro
tubules was confirmed by biochemical subcellular frac
tiona
tion. Recombinan
t Gcap14 pro
tein cosedimen
ted wi
th pure micro
tubules, indica
ting a direc
t binding be
tween
the
two. Fur
thermore, recombinan
t Gcap14 was shown
to have
the abili
ty of inducing micro
tubule bundling in vi
tro.
Structured summary of protein interactions
with by (View Interaction: , )