New dimeric and monomeric chromanones, gonytolides D-G, isolated from the fungus Gonytrichum sp.

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• 作者：Haruhisa Kikuchi ; ^{hal@mail.pharm.tohoku.ac.jp} ; Masato Isobe ; Shoichiro Kurata ; Yasuhiro Katou ; Yoshiteru Oshima
• 关键词：Bischromanone ; Tetrahydroxanthone ; Gonytrichum sp. ; Innate immunity
• 刊名：Tetrahedron
• 出版年：2012
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：5 August, 2012
• 卷：68
• 期：31
• 页码：6218-6223
• 文件大小：601 K

摘要

In the course of the screening of innate immune regulators from natural resources, we isolated new dimeric and monomeric chromanones, gonytolides D-G (trong class="boldFont">4trong>-trong class="boldFont">7trong>), from Gonytrichum sp. along with a known innate immune promoter, gonytolide A (trong class="boldFont">1trong>). The structures of these compounds were determined by spectral analysis, chemical conversion, and biogenetic consideration. The compounds trong class="boldFont">4trong>-trong class="boldFont">7trong> were evaluated on the innate immune response, indicating that the 8,8鈥?linked bischromanone rings were crucial for innate immune-promoting activity.