Increased QT dispersion in patients with insulin-dependent diabetes mellitus

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• 作者：Arildsen ; Hanne ; May ; Ole ; Christiansen ; Evald H&oslash ; j ; Damsgaard ; Else Marie
• 关键词：QT dispersion ; QT interval ; Diabetes mellitus ; Ischaemic heart disease ; Autonomic neuropathy ; Population
• 刊名：International Journal of Cardiology
• 出版年：1999
• 期刊代码：128_01675273
• 类别：med
• 出版时间：December 1, 1999
• 卷：71
• 期：3
• 页码：235-242
• 文件大小：213 K

摘要

Aim: To compare the QT dispersion in unselected patients with insulin-dependent diabetes mellitus to non-diabetic control subjects and to assess the association between the QT dispersion and cardiac autonomic neuropathy, ischaemic heart disease, blood pressure level and nephropathy. Methods: 42 patients with insulin-dependent diabetes mellitus and 80 control subjects aged 40–57 years participated. The QT interval was measured in a resting 12-lead electrocardiogram (ECG) and the QT dispersion defined as the difference between the maximum and minimum QT interval. Bazett’s formula was used to correct for heart rate (QTc). The degree of cardiac autonomic neuropathy was assessed by five function tests and ischaemic heart disease was defined by a previous myocardial infarction, ECG abnormalities or a positive exercise test. Results: Compared to control subjects, diabetic patients had a longer QTc interval (433 vs. 416 ms; P