Rheumatic mitral valve stenosis is associated with impaired flow-mediated dilatation
- 作者：Abdullah Tekin ; Gö ; knur Tekin ; Alpay Turan Sezgin ; Cem Hü ; cran ; Osman Kı ; zı ; lkı ; lı ; ç ; Tansel Erol ; Haldun Mü ; derrisoğ ; lu
- 关键词：Vascular endothelium ; Mitral stenosis ; Flow-mediated dilatation
- 刊名：International Journal of Cardiology
- 出版年：2008
- 期刊代码：128_01675273
- 类别：med
- 出版时间：25 April 2008
- 卷：125
- 期：3
- 页码：410-412
- 文件大小：92 K
摘要
It has been demonstrated that rheumatic mitral valve stenosis (RMVS) is associated with an increase in markers of endothelial dysfunction. It is not known whether this association indicates an impairment of flow-mediated dilatation (FMD) of the vascular endothelium. Thirty patients with RMVS and 30 healthy subjects were studied. FMD in patients with RMVS was significantly smaller than in healthy controls (11.9 ± 0.4%vs 15.4 ± 0.70%, p = 0.003). The absolute change in brachial artery diameter in patients with RMVS was also significantly smaller than in healthy subjects (0.42 ± 0.26 mm vs 0.64 ± 0.32 mm, p < 0.001). These findings suggest that vascular endothelial function is altered in patients with RMVS.