• 作者：Pedro Luis de Pablos-Velasco^a ; ^{ppablos@dcmq.ulpgc.es} ; ^{pablos.velasco@gmail.com} ; Francisco-Javier Ampudia-Blasco^b ; Albert Cobos^c ; ^d ; Salvador Bergoñ ; ó ; n^c ; ^e ; Pablo Pedrianes^a ; en representació ; n del Grupo de Investigadores DIABIR
• 关键词：Diabetes mellitus ; Insuficiencia renal ; Diagnó ; stico ; Factores de riesgo ; Control metabó ; lico
• 刊名：Medicina Cl铆nica
• 出版年：2010
• 期刊代码：pca254_00257753
• 类别：med
• 出版时间：20 March 2010
• 卷：134
• 期：8
• 页码：340-345
• 文件大小：177 K

Background and objective

The aim of this study was to estimate the current prevalence of Chronic Renal Insufficiency (RI) in ambulatory patients with type 2 Diabetes (T2DM) assisted in Endocrinology Departments all over Spain.

Patients and methods

This was an observational, cross sectional, multicenter study. From each participant the following data were retrospective collected: demographic, anthropometric, renal function, diabetes, cardiovascular risk factors, comorbidities and treatment. RI was defined by a glomerular filtration rate lower than 60 ml/min/1.73 m², using the shortened MDRD method.

Results

541 patients with T2DM were included, 53%were men, the mean age (DS) was 63 years old (7.9) and the HbA₁c was 7.6%(1.3). The prevalence (CI95%) of RI was 22.9%(19.4鈥?6.7), higher than the previous estimate, witch was 5,7%(3.9鈥?.0, p<0,0001). The associated risk factor for RI were age (OR 2.07; 95%CI: 1.47鈥?.91 per each ten year period of increase), female gender (OR 2.25; 95%CI: 1.36鈥?.71) and hyperuricemia (OR 3.15; 95%CI: 1.56鈥?.37). There were no differences in the metabolic control between patients with RI vs those without RI.

Conclusions

22.9%of T2DM ambulatory patients followed by endocrinologist had RI, but just a quarter of them had previously been diagnosed. The automated determination of creatinine clearance could increase the proportion of diagnosis and facilitate the improvement of the metabolic control in these patients.