Synthesis of 6H-isoindolo[2,1-a]indol-6-ones through a sequential copper-catalyzed C-N coupling and palladium-catalyzed C-H activation reaction

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• 作者：Hua-Feng He ; Sheng Dong ; Yi Chen ; Yang Yang ; Yueqin Le ; Weiliang Bao ; ^{wlbao@css.zju.edu.cn}
• 关键词：Coupling reaction ; C&ndash ; H activation ; Copper-catalysis ; Palladium-catalysis ; O-gem-Dibromovinyl aniline ; Benzoyl chloride
• 刊名：Tetrahedron
• 出版年：2012
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：8 April, 2012
• 卷：68
• 期：14
• 页码：3112-3116
• 文件大小：323 K

摘要

A series of 6H-isoindolo[2,1-a]indol-6-ones were synthesized through one-pot sequential coupling reactions, which were comprised of a copper-catalyzed C-N coupling cyclization and a palladium-catalyzed C-H activation course. General chemicals benzoyl chlorides and o-gem-dibromovinyl anilines were employed as the starting substrates.