Regional cerebral blood flow during acute and chronic abstinence from combined cocaine–alcohol abuse

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• 作者：Kosten ; Thomas R. ; Cheeves ; Catherine ; Palumbo ; Joseph ; Seibyl ; John P. ; Price ; Lawrence H. ; et. al.
• 关键词：Cerebral ; Cocaine ; Alcohol ; Perfusion defects ; Abstinence
• 刊名：Drug and Alcohol Dependence
• 出版年：1998
• 期刊代码：81_03768716
• 类别：med
• 出版时间：May 1, 1998
• 卷：50
• 期：3
• 页码：187-195
• 文件大小：436 K

摘要

Regional cerebral blood flow (rCBF) was assessed using SPECT and HMPAO in ten cocaine abusers within 72 h of last cocaine use and then after 21 days of abstinence. In comparison to normals the cocaine abusers had significantly reduced rCBF in 11 of 14 brain regions with the largest reductions in the frontal and parietal cortex and greater rCBF in the brain stem. These perfusion defects appeared to be primarily due to combined alcohol and cocaine abuse and frontal but not parietal defects appeared to resolve partially during 21 days of abstinence.