Phenolic compounds and plant extracts as potential natural anti-obesity substances

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• 作者：Thé ; rè ; se Sergent ; Jessica Vanderstraeten ; Julie Winand ; Pauline Beguin ; Yves-Jacques Schneider ; ^{yjs@uclouvain.be}
• 关键词：Lipid digestion ; Obesity ; Pancreatic lipase ; Polyphenols ; Resveratrol
• 刊名：Food Chemistry
• 出版年：2012
• 期刊代码：48_03088146
• 类别：abs
• 出版时间：1 November, 2012
• 卷：135
• 期：1
• 页码：68-73
• 文件大小：356 K

摘要

One strategy to prevent obesity could consist in the inhibition of the pancreatic lipase (PL). In an attempt to find natural antiobesity agents, phenolic compounds (PCs) and plant extracts were investigated on PL activity. Epigallocatechin-3-gallate > kaempferol and quercetin were detected as potent PL inhibitors, with ICs₅₀ of 0.8, 13.4 and 21.5 渭M, respectively. Plant extracts from green tea and grape seed also shown potent inhibitory effect. Selected PCs were then assayed in an in vitro model of simulated intestinal fat digestion, based on the lipolysis of triolein. In such conditions closer to physiological reality, resveratrol, but also epigallocatechin-3-gallate and quercetin reduced the triolein digestion to 卤50%. This could delay or decrease in vivo fatty acid absorption by enterocytes. This work therefore suggests that some PCs, at concentrations easily reached in the intestine following ingestion of tea beverages, fruits or vegetables, but also flavonoid-enriched supplements or functional food, are potential candidates for obesity prevention.