A new pancreatic lipase inhibitor from Broussonetia kanzinoki

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• 作者：Jong Hoon Ahn^a ; Qing Liu^a ; Chul Lee^a ; Mi-Jeong Ahn^b ; Hwan-Soo Yoo^a ; Bang Yeon Hwang^a ; Mi Kyeong Lee^a ; ^{mklee@chungbuk.ac.kr}
• 关键词：Broussonetia kanzinoki ; Moraceae ; Pancreatic lipase ; Broussonone A ; Adipocyte differentiation
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：15 April, 2012
• 卷：22
• 期：8
• 页码：2760-2763
• 文件大小：326 K

摘要

A new phenolic compound, broussonone A (1) were isolated from the stem barks of Broussonetia kanzinoki (Moraceae), together with two diphenylpropanes, broussonin A (2), broussonin B (3), two flavans, 7,4鈥?dihydroxyflavan (4), 3鈥?7-dihydroxy-4鈥?methoxyflavan (5), and two flavones, 3,7-dihydroxy-4鈥?methoxyflavone (6), 3,7,3鈥?trihydroxy-4鈥?methoxyflavone (7). Compound 1 showed noncompetitive inhibitory activity on pancreatic lipase with an IC₅₀ of 28.4 渭M. In addition, compounds 1-5 significantly inhibited adipocyte differentiation in 3T3-L1 cells as measured fat accumulation using Oil Red O assay.