Sudden death and lipomatous infiltration of the heart involved by fat necrosis resulting from acute pancreatitis

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• 作者：Luca Roncati^a ; ^{emailmedical@gmail.com} ; Giorgio Gualandri^b ; Giuseppe Fortuni^c ; Giuseppe Barbolini^a
• 关键词：Sudden death ; Heart steatonecrosis ; Acute pancreatitis ; Lipomatous infiltration of the heart ; Pancreatic lipase
• 刊名：Forensic Science International
• 出版年：2012
• 期刊代码：104_03790738
• 类别：med
• 出版时间：10 April, 2012
• 卷：217
• 期：1-3
• 页码：e19-e22
• 文件大小：1732 K

摘要

The possible causal link between damage to the heart and acute pancreatitis and other pancreatic diseases has been considered in both adults and children, particularly in cases of sudden, unexpected death. However, the cardiac pathological findings so far reported in the literature are neither specific enough, nor of a kind to prove a direct pancreatic pathogenesis. We describe the occurrence of steatonecrosis developed in areas of lipomatous infiltration of the heart following acute exacerbation of latent chronic pancreatitis. The presence of mature adipocytes in the myocardium is an adequate substrate for the pancreatic lipase to give rise to the steatonecrosis, which is a well-known marker of acute pancreatitis. As far as we are aware, this is the first reported case of heart steatonecrosis in the literature.