Acute smoke-induced endothelial dysfunction is more prolonged in smokers than in non-smokers

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• 作者：Kalliopi Karatzi ; Christos Papamichael ; Emmanouil Karatzis ; Theodore G. Papaioannou ; Kimon Stamatelopoulos ; Nikolaos A. Zakopoulos ; Antonis Zampelas ; John Lekakis
• 关键词：Endothelial dysfunction ; Cigarette smoking ; FMD
• 刊名：International Journal of Cardiology
• 出版年：2007
• 期刊代码：128_01675273
• 类别：med
• 出版时间：3 September 2007
• 卷：120
• 期：3
• 页码：404-406
• 文件大小：124 K

摘要

The aim of the study was to compare acute endothelial dysfunction caused by smoking one cigarette between smokers and non-smokers.

Methods

Thirty volunteers, 15 smokers and 15 non-smokers, were asked to smoke the same type of cigarette and endothelial function was assessed by FMD (flow mediated dilatation) at fast, 30, 60 and 90 min post-smoking.

Results

Overall response of FMD after smoking was significantly different between smokers and non-smokers (p = 0.011). Endothelial dysfunction after smoking remained significant for 1-h in smokers (p = 0.002), but only for 30 min in non-smokers (p = < 0.001). FMD 1-h after smoking was significantly higher in non-smokers than in smokers (p = 0.002).

Conclusions

Smokers seem to have sustained and more intensive unfavourable effects in endothelial function than non-smokers after smoking one cigarette. It is possible that long-term smoking diminishes the capacity of endothelium to counterbalance external factors that cause endothelial dysfunction.