• 作者：Sergio Obeso^a ; ^b ; José ; Luis Llorente^a ; ^b ; ^{llorentependas@telefonica.net} ; Juan Pablo Dí ; az-Molina^a ; ^b ; Rafael Sá ; nchez-Ferná ; ndez^a ; ^b ; Juan Pablo Rodrigo^a ; ^b ; Carlos Suá ; rez^a ; ^b
• 关键词：Condrosarcoma ; Cabeza y cuello ; Laringe ; Cavidad nasal ; Base de crá ; neo
• 刊名：Acta Otorrinolaringol贸gica Espa帽ola
• 出版年：2010
• 期刊代码：pca34_00016519
• 类别：med
• 出版时间：July-August 2010
• 卷：61
• 期：4
• 页码：262-271
• 文件大小：1054 K

Introduction

Head and neck chondrosarcomas may adopt different locations and biological behaviour.

Material and method

We present a retrospective clinical series of 17 chondrosarcomas surgically treated in our Department from 1977 until 2006.

Results

Chondrosarcomas were located in the nasosinusal area (n=6), larynx (n=5), petrous bone (n=3), atlas (n=1), parapharyngeal space (n=1) and trachea (n=1). All patients except for one underwent surgery with radical intention. The mean follow-up period was 84 months (median, 71 months). Six patients developed recurrent disease with a mean latency of 10 months. Two patients died due to the disease and two remained alive with evidence of tumour. Patients with grade I chondrosarcomas presented less recurrent disease than those with grade II or III chondrosarcomas (17%versus 80%, P=0.029). The estimated 5-year survival was 88%with the better survival of patients with grade I chondrosarcomas reaching statistical significance (P=0.023). In 2 patients with cricoid chondrosarcomas, the reconstruction was carried out using the Rethi-Ward technique, and they were without evidence of disease at 71 months (with no cannula) and 145 months (with cannula). Chondrosarcomas of the jugular foramen were treated using a modified infratemporal type A approach.

Conclusion

Low grade head and neck chondrosarcomas have a good prognosis while high grade chondrosarcomas tend to recur, despite radical surgical treatment.