Subject-investigator reproducibility of the Unified Parkinson鈥檚 Disease Rating Scale

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• 作者：Sydney E. Seidel^a ; ¹ ; Barbara C. Tilley^b ; ¹ ; Peng Huang^c ; ¹ ; Yuko Y. Palesch^a ; ¹ ; Kenneth J. Bergmann^d ; ¹ ; Christopher G. Goetz^e ; ¹ ; Christopher J. Swearingen^f ; ¹ ; ^{cswearingen@uams.edu}
• 关键词：UPDRS ; Parkinson&rsquo ; s disease ; Concordance correlation ; Kappa ; NET-PD
• 刊名：Parkinsonism and Related Disorders
• 出版年：2012
• 期刊代码：215_13538020
• 类别：med
• 出版时间：March, 2012
• 卷：18
• 期：3
• 页码：230-233
• 文件大小：339 K

摘要

Objective

To evaluate the subject-investigator agreement on the Unified Parkinson鈥檚 Disease Rating Scale (UPDRS) subsections I and II.

Methods

Subject-investigator agreement was estimated at baseline and endpoint by Kappa statistics for individual items and concordance correlations for subscale totals using data from two NIH Exploratory Trials in Parkinson鈥檚 Disease studies.

Results

All but two questions had moderate subject-investigator agreement at baseline and endpoint. Participants consistently rated their disease activity worse that investigators.

Conclusion

UPDRS self-administration produces similar results to investigator-administration. Although slightly elevated, UPDRS self-administration can be accommodated in a clinical trial setting.