Fibrinogen 纬鈥?levels in patients with intracerebral hemorrhage

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• 作者：E.G. van den Herik^a ; ^{e.vandenherik@erasmusmc.nl} ; E.Y.L. Cheung^b ; L.M.L. de Lau^a ; H.M. den Hertog^a ; F.W.G. Leebeek^b ; D.W.J. Dippel^a ; P.J. Koudstaal^a ; M.P.M. de Maat^b
• 关键词：纬&rsquo ; fibrinogen 纬&rsquo ; mRNA ; messenger ribonucleic acid ; ICH ; intracerebral hemorrhage ; IVE ; intraventricular extension ; ESS ; Erasmus Stroke Study ; mRS ; modified Rankin Scale ; OR ; odds ratio ; SD ; standard deviation ; CI ; confidence interval
• 刊名：Thrombosis Research
• 出版年：2012
• 期刊代码：247_00493848
• 类别：med
• 出版时间：June, 2012
• 卷：129
• 期：6
• 页码：807-809
• 文件大小：139 K

摘要

Background

The fibrinogen 纬鈥?variant (纬鈥? has both antithrombotic and prothrombotic properties when compared to normal fibrinogen. It may therefore be of relevance in intracerebral hemorrhage and intraventricular extension of the bleeding.

Objective

To study the role of 纬鈥?in intracerebral hemorrhage, and in intraventricular extension of the hemorrhage.

Patients/Methods

We performed a case-control study in 156 controls and 55 patients with intracerebral hemorrhage, with and without intraventricular extension. Levels of fibrinogen 纬鈥?and the 纬鈥?total fibrinogen ratio were measured in all participants.

Results

Levels of 纬鈥?were increased in patients with intracerebral hemorrhage when compared with controls (0.40 vs 0.32 g/l, p < 0.001). The 纬鈥?total fibrinogen ratio was similar in patients and controls (0.092 vs 0.096 p = 0.42). There was evidence for an unfavorable outcome in patients with fibrinogen levels in the highest tertile compared with the lowest tertile (OR 4.0, 95%CI 1.1-15.2), and a nonsignificant trend toward unfavorable outcome with higher levels of 纬鈥?(p-value for trend = 0.06).

Conclusions

Our study shows that absolute levels of fibrinogen 纬鈥?are increased in patients with intracerebral hemorrhage, but relative levels are similar in patients and controls, suggesting that the absolute rise in 纬鈥?is an acute phase response.