To study the role of 纬鈥?in intracerebral hemorrhage, and in intraventricular extension of the hemorrhage.
We performed a case-control study in 156 controls and 55 patients with intracerebral hemorrhage, with and without intraventricular extension. Levels of fibrinogen 纬鈥?and the 纬鈥?total fibrinogen ratio were measured in all participants.
Levels of 纬鈥?were increased in patients with intracerebral hemorrhage when compared with controls (0.40 vs 0.32 g/l, p < 0.001). The 纬鈥?total fibrinogen ratio was similar in patients and controls (0.092 vs 0.096 p = 0.42). There was evidence for an unfavorable outcome in patients with fibrinogen levels in the highest tertile compared with the lowest tertile (OR 4.0, 95%CI 1.1-15.2), and a nonsignificant trend toward unfavorable outcome with higher levels of 纬鈥?(p-value for trend = 0.06).
Our study shows that absolute levels of fibrinogen 纬鈥?are increased in patients with intracerebral hemorrhage, but relative levels are similar in patients and controls, suggesting that the absolute rise in 纬鈥?is an acute phase response.