Elevated HLA-E levels in human glioblastomas but not in grade I to III astrocytomas correlate with infiltrating CD8+ cells
- 作者：Michel Mittelbronn ; Perikles Simon ; Christian Lö ; ffler ; David Capper ; Benedikt Bunz ; Patrick Harter ; Holger Schlaszus ; Ariane Schleich ; Ghazaleh Tabatabai ; Benjamin Goeppert ; Richard Meyermann ; Mi
- 关键词：HLA-E ; CD8 ; Cytotoxic T cells ; NK cells ; Human astrocytomas ; Immune escape
- 刊名：Journal of Neuroimmunology
- 出版年：2007
- 期刊代码：32_01655728
- 类别：neu
- 出版时间：September 2007
- 卷：189
- 期：1-2
- 页码：50-58
- 文件大小：1596 K
摘要
HLA-E is a ligand for the immune-inhibitory NKG2A receptor expressed on NK and T cells. To investigate HLA-E expression and immune cell infiltration in human astrocytic tumors in vivo, we analyzed normal CNS controls and astrocytomas of all WHO grades by immunohistochemistry. Both, CD8+ immune cell infiltration and HLA-E expression were significantly higher in astrocytic tumors than in normal brain. Further, HLA-E expression levels and immune cell infiltration were significantly correlated in WHO grade IV glioblastomas. Thus, HLA-E overexpression in glioblastomas may be triggered by T and NK cell infiltration.