• 作者：I. Gonzá ; lez-Busto Mú ; gica^a ; ^{ignaciobusto@gmail.com} ; J. Prieto Rodrí ; guez^b ; A. Ferná ; ndez^c ; R. Hueso Rieu^a ; F.V. Á ; lvarez Mené ; ndez^d ; A. Amigo Ferná ; ndez^a
• 关键词：Procalcitonina ; Diagnó ; stico de infecció ; n ; Artroplastia ; Rodilla
• 刊名：Revista Espa帽ola de Cirug铆a Ortop茅dica y Traumatolog铆a
• 出版年：2011
• 期刊代码：pca311_18884415
• 类别：med
• 出版时间：March-April 2011
• 卷：55
• 期：2
• 页码：130-139
• 文件大小：237 K

Purpose of the study

Procalcitonin (PCT) is a 116 aminoacid polipeptyde synthesized in the thyroid C-cells. Its levels rise in the presence of bacterial infection. The aim of this work was to study the evolution of PCT levels in the postoperative period of knee arthroplasty and to assess its usefulness in the diagnosis of the infection process and its relationship to Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP).

Material and methods

Blood samples from 128 patients undergoing total knee arthroplasty surgery were taken one hour before surgery and 24, 48 and 72 hours after. PCT, ESR and CRP levels were measured and related to clinical complications. The number of leukocytes, blood transfusions, type of implant and minutes of ischaemia were studied and correlated to PCT concentrations above 0.5 ng/mL.

Results

PCT < 0.5 ng/mL correlated with absence of clinical complications in 95%of the cases, and levels of PCT>0.5 ng/mL correlated to clinical complications in 75%of the cases. ESR and CRP increased in all of the patients in the postoperative period.

Conclusions

Difficulties in establishing an unquestionable diagnosis of infection do not allow us to firmly assert that PCT levels higher than 0.5 ng/mL are exclusive of bacterial infection, but it does seem to be more useful than ESR and CRP in the management of these patients.