Multimodality functional imaging of spontaneous canine tumors using ⁶⁴Cu-ATSM and ¹⁸FDG PET/CT and dynamic contrast enhanced perfusion CT

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• 作者：Anders E. Hansen^a ; ^{aeha@life.ku.dk} ; Annemarie T. Kristensen^a ; Ian Law^b ; Fintan J. McEvoy^a ; Andreas Kjæ ; r^b ; ^c ; Svend A. Engelholm^d
• 关键词：Cu-ATSM ; FDG ; Hypoxia ; Perfusion CT
• 刊名：Radiotherapy and Oncology
• 出版年：2012
• 期刊代码：231_01678140
• 类别：med
• 出版时间：March, 2012
• 卷：102
• 期：3
• 页码：424-428
• 文件大小：387 K

摘要

Purpose

To compare the distribution and uptake of the hypoxia tracer ⁶⁴Cu-diacetyl-bis(N⁴-methylthiosemicarbazone) (⁶⁴Cu-ATSM) PET/CT, FDG PET/CT and dynamic contrast enhanced perfusion CT (DCE-pCT) in spontaneous canine tumors. In addition ⁶⁴Cu-ATSM distribution over time was evaluated.

Methods and materials

Nine spontaneous cancer-bearing dogs were prospectively enrolled. FDG (1 h pi.) and ⁶⁴Cu-ATSM (3 and 24 h pi.) PET/CT were performed over three consecutive days. DCE-pCT was performed on day 2. Tumor uptake of FDG and ⁶⁴Cu-ATSM was assessed semi-quantitatively and the distribution of FDG, ⁶⁴Cu-ATSM and CT perfusion parameters correlated.

Results

⁶⁴Cu-ATSM distribution on scans performed 24 h apart displayed moderate to strong correlation; however, temporal changes were observed. The spatial distribution pattern of ⁶⁴Cu-ATSM between scans was moderately to strongly positively correlated to FDG, whereas the correlation of CT perfusion parameters to FDG and to ⁶⁴Cu-ATSM yielded more varying results.

Conclusions

⁶⁴Cu-ATSM uptake was positively correlated to FDG. ⁶⁴Cu-ATSM was found to be relatively stable between PET scans performed at different time points, important temporal changes were however observed in hypo-perfused regions. These findings potentially indicate that prolonged uptake periods for ⁶⁴Cu-ATSM imaging may be needed. Although a moderate to strong correlation between ⁶⁴Cu-ATSM and FDG PET/CT is observed, the two tracers provide different biological information with an overlapping spatial distribution.