Role of PD-L1/PD-1 in the immune response to respiratory viral infections

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• 作者：Mihnea Tudor Zdrenghea^a ; ^{mzdrenghea@umfcluj.ro} ; Sebastian Lennox Johnston^b
• 关键词：PD-1 ; B7-H1 ; B7-DC ; Viruses
• 刊名：Microbes and Infection
• 出版年：2012
• 期刊代码：65_12864579
• 类别：imm
• 出版时间：June, 2012
• 卷：14
• 期：6
• 页码：495-499
• 文件大小：119 K

摘要

Airway epithelial cells are the main cells infected by respiratory viruses including rhinoviruses and respiratory syncytial virus. Virus modulation of inhibitory molecule PD-L1 on epithelial cells may be important in limiting anti-viral effector CD8⁺ T cell responses and, consequently, worsening acute virus-induced lung tissue damage.