To test the performing characteristics for several thresholds (1-14%) and to examine the overall accuracy and calibration plot of the EAU nomogram at our institution. The study population consisted of 3081 patients treated with RP and PLND limited to the obturator fossa and the external iliac vein between 2008 and 2010 at a single European institution from Germany. More extensive PLNDs were performed at the surgeon鈥檚 discretion.
Overall, 260 patients (9.2%) had LNI. The 7%threshold would have avoided 30%of PLNDs, at the cost of missing 8%of patients with LNI. The use of 8%and 9%threshold would have allowed the avoidance of respectively 39%and 48%of PLNDs, at the cost of missing respectively 12%and 14%of patients with LNI. The accuracy of the LNI nomogram was 78%, and the unadjusted departure from ideal calibration was 5.3%.
We confirmed adequate accuracy and calibration of the LNI nomogram. The 7%cut-off may be overly conservative. Better trade-offs between avoided PLNDs and missed LNI cases may be achieved with a limit of 8 or even 9%.