Interaction of the N-Terminal Domain of the AMPA Receptor GluR4 Subunit with the Neuronal Pentraxin NP1 Mediates GluR4 Synaptic Recruitment
- 作者：Gek-Ming Sia ; Jean-Claude Bé ; ï ; que ; Gavin Rumbaugh ; Richard Cho ; Paul F. Worley ; Richard L. Huganir
- 关键词：SYSNEURO
- 刊名：Neuron
- 出版年：2007
- 期刊代码：45_08966273
- 类别：neu
- 出版时间：2 August 2007
- 卷：55
- 期：3
- 页码：533
- 文件大小：29 K
摘要
The real world presents our sensory systems with a continuous stream of undifferentiated information. Segmentation of this stream at event boundaries is necessary for object identification and feature extraction. Here, we investigate the neural dynamics of event segmentation in entire musical symphonies under natural listening conditions. We isolated time-dependent sequences of brain responses in a 10 s window surrounding transitions between movements of symphonic works. A strikingly right-lateralized network of brain regions showed peak response during the movement transitions when, paradoxically, there was no physical stimulus. Model-dependent and model-free analysis techniques provided converging evidence for activity in two distinct functional networks at the movement transition: a ventral fronto-temporal network associated with detecting salient events, followed in time by a dorsal fronto-parietal network associated with maintaining attention and updating working memory. Our study provides direct experimental evidence for dissociable and causally linked ventral and dorsal networks during event segmentation of ecologically valid auditory stimuli.