Effect of medroxyprogesterone on development of pentylenetetrazole-induced kindling in mice

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• 作者：S.A. Nasir^a ; A. Sharma^b ; R. Khanam^a ; D. Vohora^a ; ^{dvohra@jamiahamdard.ac.in} ; ^{divyavohora@hotmail.com}
• 关键词：medroxyprogesterone ; mifepristone ; diazepam ; PTZ kindling ; grip strength ; spontaneous alternation behavior
• 刊名：Neuroscience
• 出版年：2012
• 期刊代码：50_03064522
• 类别：neu
• 出版时间：5 April, 2012
• 卷：207
• 期：Complete
• 页码：283-287
• 文件大小：248 K

摘要

In the present study, the effect of medroxyprogesterone (MPA) is evaluated for its effect on pentylenetetrazole (PTZ) kindling model of epileptogenesis in mice followed by evaluation on kindling-induced changes in cognitive and motor functions. To explore whether the effects are mediated via progesterone receptors, a selective antagonist of progesterone (mifepristone, MIF) was also taken. Kindling was induced by once every 2 days treatment with PTZ (25 mg/kg, i.p.) for 5 weeks. The seizure severity during induction of kindling and%incidence of animals kindled at the end of 5 weeks were recorded. The motor function was assessed using a grip strength meter, whereas spatial memory was assessed in a cross maze. MPA (5 and 10 mg/kg, i.p.) significantly reduced the seizure severity scores and produced a significant decrease in the incidence of animals kindled at the end of 5 weeks (P<0.01). A higher efficacy was observed against male mice as compared with females following MPA. MIF neither reduced nor delayed the development of PTZ-induced kindling in mice. Also, it couldn't reverse the antiepileptogenic effects of MPA. On grip strength test (GST) and spontaneous alternation behavior (SAB), a significant decline in GST and%alternation was observed in kindled mice which was reversed by pre-treatment with MPA. MIF, however, could reverse only the reduced%alternation and not grip strength (GS) in PTZ-kindled animals. The study shows that MPA has antiepileptogenic effects against development of PTZ-induced kindling in mice that may not be mediated via progesterone receptors.