Hyperthermic seizures enhance responsiveness to pentylenetetrazole and induce cognitive dysfunction: Protective effect of 3-alkynyl selenophene

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• 作者：Ethel Antunes Wilhelm¹ ; Ana Cristina Guerra Souza¹ ; Bibiana Mozzaquatro Gai¹ ; Pietro M. Chagas¹ ; Juliano Alex Roehrs¹ ; Cristina Wayne Nogueira¹ ; ^{criswn@quimica.ufsm.br}
• 关键词：Hyperthermia ; 3-alkynyl selenophene ; Selenium ; Diazepam ; Memory
• 刊名：Life Sciences
• 出版年：2012
• 期刊代码：62_00243205
• 类别：imm
• 出版时间：15 May, 2012
• 卷：90
• 期：17-18
• 页码：666-672
• 文件大小：585 K

摘要

Aims

In this study we investigated the effect of pre-treatment with 3-alkynyl selenophene (3-ASP) against the increase in responsiveness to pentylenetetrazole [PTZ seizure threshold] and cognitive dysfunction induced by experimental febrile seizures (FS). The effects of 3-ASP were compared to those of diazepam (DZP).

Main methods

Young rats, at postnatal day 21, developed seizures after exposure to a stream of heated air to approximately 41 掳C. A non-spatial long-term memory and PTZ seizure threshold were determined 30 days after FS. The behavioural seizures were stereotyped followed by facial automatisms, often followed by body flexion. Young rats were pre-treated with 3-ASP (50 and 100 mg/kg; per oral route), DZP (1 and 5 mg/kg; intraperitoneally) or vehicle.

Key findings

3-ASP and DZP pre-treatments were not effective in protecting against seizures induced by FS. 3-ASP pre-treatment protected against the increase in responsiveness to PTZ and cognitive dysfunction induced by FS. DZP pre-treatment was effective in protecting against the increase in responsiveness to PTZ, but not, against the impaired memory induced by FS.

Significance

3-ASP pre-treatment protected against impairment of memory performance in the step-down passive avoidance task and the increase in the susceptibility to seizures caused by FS early in life of rats.