Peptides in cancer nanomedicine: Drug carriers, targeting ligands and protease substrates

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• 作者：Xiao-Xiang Zhang ; Henry S. Eden ; Xiaoyuan Chen ; ^{shawn.chen@nih.gov}
• 关键词：Peptides ; Cancer ; Nanomedicine ; Drug delivery ; Tumor targeting ; Protease-responsive
• 刊名：Journal of Controlled Release
• 出版年：2012
• 期刊代码：25_01683659
• 类别：pha
• 出版时间：10 April, 2012
• 卷：159
• 期：1
• 页码：2-13
• 文件大小：899 K

摘要

Peptides are attracting increasing attention as therapeutic agents, as the technologies for peptide development and manufacture continue to mature. Concurrently, with booming research in nanotechnology for biomedical applications, peptides have been studied as an important class of components in nanomedicine, and they have been used either alone or in combination with nanomaterials of every reported composition. Peptides possess many advantages, such as smallness, ease of synthesis and modification, and good biocompatibility. Their functions in cancer nanomedicine, discussed in this review, include serving as drug carriers, as targeting ligands, and as protease-responsive substrates for drug delivery.