Spirometric profile of narghile smokers

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• 作者：H. Ben Saad^a ; ^b ; ^g ; ^{helmi.bensaad@rns.tn} ; M. Khemis^a ; I. Bougmiza^c ; C. Prefaut^b ; H. Aouina^d ; N. Mrizek^e ; A. Garrouche^f ; A. Zbidi^a ; Z. Tabka^a
• 关键词：Spirometry ; Tobacco ; Narghile ; Deficit ; Ageing
• 刊名：Revue des Maladies Respiratoires
• 出版年：2011
• 期刊代码：pca332_07618425
• 类别：med
• 出版时间：September 2011
• 卷：28
• 期：7
• 页码：e39-e51
• 文件大小：609 K

摘要

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Summary

Introduction

Studies of the spirometric profiles of narghile smokers are few, have some methodological limits (i.e. small sample size), and present contradictory conclusions.

Aims

(i) To determine the percentage of narghile smokers with obstructive ventilatory defect (OVD) and/or restrictive ventilatory defect (RVD) or static hyperinflation (SHI); (ii) to compare the chronological and estimated lung ages.

Population and methods

Inclusion criteria: men aged 20 to 60 years, narghile smokers (> 1 narghile-year [NY]). Exclusion criteria: cigar or cigarette smokers and comorbidity. Narghile use quantification: NY and kg of cumulative tobacco use (1 NY = 9.125 kg of cumulative tobacco use).

Definitions

Large airway obstructive ventilatory defect (OVD): forced expired volume in one second (FEV₁) / forced vital capacity (FVC) less than lower limit of normal (LLN). Small airway OVD: FVC more than LLN and decrease (less than LLN) of one or more peripheral flows. RVD: total lung capacity (TLC) less than LLN. SHI: residual volume (RV) more than upper limit of normal.

Spirometric measures

(Vmax 22 Series/6200 Autobox, SensorMedics, Yorba Linda, California, USA with measurement of functional residual capacity by nitrogen washout). Measurements were made according to international recommendations.

Results

One hundred and ten narghile smokers were included (34 卤 10 years; 1.76 卤 0.07 m; 84 卤 14 kg). Thirty-six percent of the subjects had SHI; 14%had small airway OVD; 14%had RVD, and 6%had large airway OVD. Estimated lung age was higher than chronological lung age (47 卤 18 years vs. 34 卤 10 years, P < 0.05).

Conclusion

Narghile use accelerates lung ageing. This study provides the health authorities with valid arguments to fight this blight on society, which increasingly involves children and pregnant women.