Contrast-enhanced ultrasonic parametric perfusion imaging in the evaluation of antiangiogenic tumor treatment

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• 作者：Jian-Hua Zhou^a ; ¹ ; ² ; ^{zjh96421@hotmail.com} ; Wei Zheng^a ; ¹ ; ² ; ^{zhengwei@sysucc.org.cn} ; Long-Hui Cao^b ; ³ ; ^{clhforever@hotmail.com} ; Min Liu^a ; ² ; ^{minliu83@hotmail.com} ; Rong-Zhen Luo^c ; ⁴ ; ^{luorzhen@mail.sysu.edu.cn} ; Feng Han^a ; ² ; ^{hanfeng@sysucc.org.cn} ; Pei-Hong Wu^d ; ^{peihong.wu@hotmail.com} ; An-Hua Li^a ; ^{anhuali@hotmail.com}
• 关键词：Antiangiogenic therapy ; Perfusion ; Contrast-enhanced ultrasound ; Parametric perfusion imaging ; Tumor
• 刊名：European Journal of Radiology
• 出版年：2012
• 期刊代码：93_0720048x
• 类别：med
• 出版时间：June, 2012
• 卷：81
• 期：6
• 页码：1360-1365
• 文件大小：982 K

摘要

Purpose

To assess the validity of contrast-enhanced ultrasonic parametric perfusion imaging in the evaluation of antiangiogenic tumor treatment by using histology as the reference standard.

Materials and methods

H22 hepatoma-bearing mice were treated with thalidomide or placebo by intraperitoneal injection. Contrast-enhanced ultrasound was performed on day 8 after bolus injection of SonoVue. Three different parametric perfusion images were calculated based on the following parameters: area under the curve (AUC), maximum intensity (IMAX) and perfusion index (PI). A score from 1 to 5 (1 = low, 5 = excellent) was used for analysis of parametric perfusion images by two independent readers. Immunohistochemical analysis was performed for evaluation of microvascular density (MVD).

Results

Treatment with thalidomide resulted in a significant decrease in perfusion scores assigned to AUC, IMAX and PI parametric images as compared with control tumors (P < 0.001). Immunohistochemistry showed significant decreases of MVD in treated tumors as compared with control tumors (P = 0.002). MVD was positively correlated with the perfusion scores assigned to AUC parametric images (r = 0.568, P = 0.009), IMAX parametric images (r = 0.614, P = 0.004) and PI parametric images (r = 0.636, P = 0.003).

Conclusion

Contrast-enhanced ultrasonic parametric perfusion imaging provides a noninvasive tool to directly visualize tumor perfusion changes after antiangiogenic tumor treatment.