Cerebral metabolism and mood in remitted opiate dependence

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• 作者：Igor I. Galynker ; Daniel Eisenberg ; John A. Matochik ; Enid Gertmenian-King ; Lisa Cohen ; Alane S. Kimes ; Carlo Contoreggi ; Varughese Kurian ; Monique Ernst ; Richard N. Rosenthal ; James Prosser ; Edythe
• 关键词：Methadone ; Heroin ; Abstinence ; Depression ; Mood ; Positron emission tomography
• 刊名：Drug and Alcohol Dependence
• 出版年：2007
• 期刊代码：81_03768716
• 类别：med
• 出版时间：8 October 2007
• 卷：90
• 期：2-3
• 页码：166-174
• 文件大小：494 K

摘要

Opiate-dependent individuals are prone to dysphoria that may contribute to treatment failure. Methadone-maintenance therapy (MMT) may mitigate this vulnerability, but controversy surrounds its long-term use. Little is known about the neurobiology of mood dysregulation in individuals receiving or removed from MMT.

Methods

Fifteen opiate-abstinent and 12 methadone-maintained, opiate-dependent subjects, who lacked other Axis I pathology, and 13 control subjects were compared on the Cornell Dysthymia Rating Scale (CDRS) and regional cerebral glucose metabolism (rCMRglc) using [¹⁸F]fluorodeoxyglucose positron emission tomography.

Results

CDRS scores showed no group differences. Opiate-abstinent subjects had lower rCMRglc than control subjects in the bilateral perigenual anterior cingulate cortex (ACC), left mid-cingulate cortex, left insula and right superior frontal cortex. Methadone-maintained subjects exhibited lower rCMRglc than control subjects in the left insula and thalamus. In opiate-abstinent subjects, rCMRglc in the left perigenual ACC and mid-cingulate cortex correlated positively with CDRS scores.

Conclusions

In remitted heroin dependence, opiate-abstinence is associated with more widespread patterns of abnormal cortical activity than MMT. Aberrant mood processing in the left perigenual ACC and mid-cingulate cortex, seen in opiate-abstinent individuals, is absent in those receiving MMT, suggesting that methadone may improve mood regulation in this population.