Impaired carotid and femoral viscoelastic properties and elevated intima–media thickness in peripheral vascular disease

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• 作者：Cheng ; Koon-Sung ; Tiwari ; Alok ; Baker ; Cara R. ; Morris ; Richard ; Hamilton ; George ; Seifalian ; Alexander M.
• 关键词：Peripheral vascular disease ; Carotid artery ; Femoral artery ; Viscoelastic properties ; Compliance ; Elastic modulus ; Stiffness index ; Intima&ndash ; media thickness
• 刊名：Atherosclerosis
• 出版年：2002
• 期刊代码：28_00219150
• 类别：med
• 出版时间：September, 2002
• 卷：164
• 期：1
• 页码：113-120
• 文件大小：258 K

摘要

Background: We undertook a study to determine whether peripheral vascular disease of the lower extremity (PVD) per se affects the arterial viscoelastic properties and intima–media thickness (IMT) of the carotid and femoral arteries. Methods: Thirty-five patients with PVD, 35 age- and gender-matched control subjects were examined with ultrasound scan wall tracking system, with the simultaneous measurement of blood pressure for carotid and femoral IMT and viscoelastic properties. Results: Subjects with PVD have significantly impaired carotid elastic properties including compliance (mean (SD): 6.50 (2.39) vs 9.93 (4.07)%mmHg⁻¹×10⁻², P<0.001), Petersen's elastic modulus (1.77 (0.69) vs 1.19 (0.63) mmHg×10³, P