Distinct Neural Stem Cell Populations Give Rise to Disparate Brain Tumors in Response to N-MYC

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• 作者：Fredrik  ; J. Swartling¹ ; ² ; ^{fredrik.swartling@igp.uu.se} ; Vasil Savov² ; ⁵ ; Anders  ; I. Persson¹ ; ⁵ ; Justin Chen¹ ; Christopher  ; S. Hackett¹ ; Paul  ; A. Northcott³ ; Matthew  ; R. Grimmer¹ ; Jasmine Lau¹ ; Louis Chesler⁴ ; Arie Perry¹ ; Joanna  ; J. Phillips¹ ; Michael  ; D. Taylor³ ; William  ; A. Weiss¹ ; ^{waweiss@gmail.com}
• 刊名：Cancer Cell
• 出版年：2012
• 期刊代码：43_15356108
• 类别：med
• 出版时间：15 May, 2012
• 卷：21
• 期：5
• 页码：601-613
• 文件大小：1743 K

摘要

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class="h3">Summary

The proto-oncogene MYCN is mis-expressed in various types of human brain tumors. To clarify how developmental and regional differences influence transformation, we transduced wild-type or mutationally stabilized murine N-myc^T58A into neural stem cells (NSCs) from perinatal murine cerebellum, brain stem, and forebrain. Transplantation of N-myc^WT NSCs was insufficient for tumor formation. N-myc^T58A cerebellar and brain stem NSCs generated medulloblastoma/primitive neuroectodermal tumors, whereas forebrain NSCs developed diffuse glioma. Expression analyses distinguished tumors generated from these different regions, with tumors from embryonic versus postnatal cerebellar NSCs demonstrating Sonic Hedgehog (SHH) dependence and SHH independence, respectively. These differences were regulated in part by the transcription factor SOX9, activated in the SHH subclass of human medulloblastoma. Our results demonstrate context-dependent transformation of NSCs in response to a common oncogenic signal.