UK and Canadian infants were immunised with 2-3 doses of MenACWY-CRM197 or 2 doses of serogroup C meningococcal (MenC) conjugate vaccine, and either MenACWY-CRM197, 1/5 dose of MenACWY polysaccharide vaccine or no booster at 12 months. Control groups recruited at 60 months had received country-specific infant doses of MenC conjugate vaccine. hSBA titres were measured in participants at 40 and 60 months of age.
382 children were enrolled in 12 groups (22-40 per group). By age 60 months, 3-11%of children primed and boosted with MenACWY-CRM197 had hSBA titres 鈮?#xA0;1:8 against serogroup A, 14-45%against serogroup C, 57-85%against serogroup W-135 and 42-71%against serogroup Y. Children primed with MenC and boosted with MenACWY-CRM197 had similar results, except for serogroup C (59%). In age-matched controls administered MenC vaccine at 2, 3, and 4 months (UK), 2 and 12 months or 12 months only (Canada), percentages with hSBA titres 鈮?#xA0;1:8 were 0-3%, 29-53%, 34-36%and 10-29%against serogroups A, C, W-135 and Y respectively.
Serogroup-specific bactericidal antibody wane following infant immunisation with MenACWY-CRM197, most markedly against serogroup A. Best persistence against serogroup C is observed with MenC conjugate vaccine priming and MenACWY-CRM197 at 12 months, compared to schedules using only MenACWY-CRM197, with the potential for providing broader protection compared to monovalent MenC vaccines alone.