- 作者：Antonio Camargo<sup>asup><sup> ; sup><sup>1sup> ; Juan Ruano<sup>asup><sup> ; sup><sup>1sup> ; Juan M. Ferná ; ndez<sup>asup> ; Laurence D. Parnell<sup>bsup> ; Anabel Jimé ; nez<sup>asup> ; Monica Santos-Gonzá ; lez<sup>csup> ; Carmen Marí ; n<sup>asup> ; Pablo Pé ; rez-Martí ; nez<sup>asup> ; Marino Uceda<sup>dsup> ; José ; Ló ; pez-Miranda<sup>asup> ; Francisco Pé ; rez-Jimé ; nez<sup>asup><sup> ; sup><sup>fperezjimenez@uco.essup>
- 关键词：Aceite de oliva ; Compuestos fenó ; licos ; Factores de transcripció ; n ; Sí ; ndrome metabó ; lico ; Aterosclerosis
- 刊名：Cl铆nica e Investigaci贸n en Arteriosclerosis
- 出版年：2011
- 期刊代码：pca88_02149168
- 类别：med
- 出版时间：November-December 2011
- 卷：23
- 期：6
- 页码：262-268
- 文件大小：247 K
ss="h4">Introduction
It has been speculated that the potential beneficial effects of olive oil could be due to modulation of genes involved in proliferative, antioxidant and inflammatory pathways. Research on the acting and mechanisms of phenolic compounds indicates that the beneficial effects associated with these compounds may not only be due to the elimination of free radicals, but could also modulate cell signalling processes, or could themselves act as signaling molecules.
ss="h4">Methods
Two virgin olive oil-based breakfasts with high (398 ppm) and low (70 ppm) content of phenolic compounds were administered to 20 patients with metabolic syndrome following a double-blinded random crossover design. Postprandial gene expression in peripheral blood mononuclear cells was analyzed at 4 hours by gene expression microarrays.
ss="h4">Results
We observed that the phenolic compounds of olive oil repressed the expression of 18 genes directly related to signalling processes, including 12 transcription factors involved in proliferation and cell growth.
ss="h4">Conclusions
Our results suggest that consumption of olive oil rich in phenolic compounds reduces the processes of cell proliferation in mononuclear cells in the postprandial state, which could reduce development of atherosclerosis.