Estrogen receptors α and β mediate different aspects of the facilitatory effects of female cues on male risk taking

详细信息	查看全文 | 推荐本文 |

• 作者：Martin Kavaliers ; Nino Devidze ; Elena Choleris ; Melissa Fudge ; Jan-Å ; ke Gustafsson ; Kenneth S. Korach ; Donald W. Pfaff ; Sonoko Ogawa
• 关键词：Boldness ; Decision making ; Predator odor ; Anxiety ; Fear ; Social behavior ; Social recognition ; Sexual motivation
• 刊名：Psychoneuroendocrinology
• 出版年：2008
• 期刊代码：228_03064530
• 类别：med
• 出版时间：June 2008
• 卷：33
• 期：5
• 页码：634-642
• 文件大小：294 K

摘要

Male risk taking and decision making are affected by sex-related cues, with men making poorer and riskier decisions in the presence of females and, or their cues. In non-human species, female cues can also increase male risk taking, reducing their responses to predator threat. As estrogen receptors www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0"> and β (ERwww.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0"> and ERβ) are involved in the mediation of social and sexual responses, we investigated their roles in determining the effects of female-associated cues on male risk taking. We examined the effects of brief pre-exposure to the odors of either a novel or familiar estrous female on the avoidance of, and aversive responses to, predator threat (cat odor) in ERwww.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0"> and ERβ wild type (www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0">ERWT, βERWT) and gene-deleted (knockout, www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0">ERKO, βERKO) male mice. Exposure of www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0">ERWT and βERWT males to the odors of a novel, but not a familiar, estrous female mouse resulted in enhanced risk taking with the males displaying reduced avoidance of, and analgesic responses to, cat odor. In contrast, www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0">ERKO male mice failed to show any changes in risk taking, while βERKO males, although displaying greater risk taking, did not distinguish between novel and familiar females, displaying similarly reduced avoidance responses to cat odor after exposure to either a novel or familiar female odor. These findings indicate that the gene for ERwww.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0"> is associated with the sexual mechanisms (response to estrous female) and the genes for ERβ and ERwww.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0"> with the social (recognition of novel female) mechanisms underlying the effects of female cues on male risk taking.