Toxicological evaluation of ammonium perfluorobutyrate in rats: Twenty-eight-day and ninety-day oral gavage studies

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• 作者：John L. Butenhoff^a ; ^{jlbutenhoff@mmm.com} ; James A. Bjork^b ; ^{jbjork1@d.umn.edu} ; Shu-Ching Chang^a ; ^{s.chang@mmm.com} ; David J. Ehresman^a ; ^{djehresman@mmm.com} ; George A. Parker^c ; ^{gparker@biotechnics-inc.com} ; Kaberi Das^d ; ^{das.kaberi@epa.gov} ; Christopher Lau^d ; ^{lau.christopher@epa.gov} ; Paul H. Lieder^a ; ^{phlieder1@mmm.com} ; Franç ; ois M. van Otterdijk^e ; ^{francois.van.otterdijk@notox.nl} ; Kendall B. Wallace^b ; ^{kwallace@d.umn.edu}
• 关键词：Perfluorobutyrate (PFBA) ; Perfluorooctanoate (PFOA) ; Repeat-dose toxicity ; Rats
• 刊名：Reproductive Toxicology
• 出版年：2012
• 期刊代码：233_08906238
• 类别：med
• 出版时间：July, 2012
• 卷：33
• 期：4
• 页码：513-530
• 文件大小：635 K

摘要

Sequential 28-day and 90-day oral toxicity studies were performed in male and female rats with ammonium perfluorobutyrate (NH₄⁺PFBA) at doses up to 150 and 30 mg/kg-d, respectively. Ammonium perfluorooctanoate was used as a comparator at a dose of 30 mg/kg-d in the 28-day study. Female rats were unaffected by NH₄⁺PFBA. Effects in males included: increased liver weight, slight to minimal hepatocellular hypertrophy; decreased serum total cholesterol; and reduced serum thyroxin with no change in serum thyrotropin. During recovery, liver weight, histological, and cholesterol effects were resolved. Results of RT-qPCR were consistent with increased transcriptional expression of the xenosensor nuclear receptors PPAR伪 and CAR as well as the thyroid receptor, and decreased expression of Cyp1A1 (Ah receptor-regulated). No observable adverse effect levels (NOAELs) were 6 and >150 mg/kg-d for male and female rats in the 28-day study and 6 and >30 mg/kg-d in the 90-dat study, respectively.