Low glycemic index treatment for epilepsy in tuberous sclerosis complex

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• 作者：Anna M. Larson ; Heidi H. Pfeifer ; Elizabeth A. Thiele ; ^{ethiele@partners.org}
• 关键词：Tuberous sclerosis complex ; Epilepsy ; Low glycemic index treatment ; Ketogenic diet ; mTOR pathway
• 刊名：Epilepsy Research
• 出版年：2012
• 期刊代码：87_09201211
• 类别：med
• 出版时间：March, 2012
• 卷：99
• 期：1-2
• 页码：180-182
• 文件大小：144 K

摘要

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Summary

Retrospective chart review of 15 patients with tuberous sclerosis complex (TSC) who initiated the low glycemic index treatment (LGIT) for epilepsy management at Massachusetts General Hospital over a five-year period. Prior to dietary therapy, this cohort (average age: 8.5 years) had tried an average of 5.8 anti-epileptic drugs with incomplete seizure control. At 6 months on the LGIT, 7/15 (47%) patients experienced >50%reduction in seizure frequency.