Regulation of CD44 expression by tumor necrosis factor-伪 and its potential role in breast cancer cell migration

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• 作者：Jun Li^a ; ¹ ; Xiao-Ming Zha^c ; ¹ ; Rong Wang^a ; Xiao-Dong Li^a ; ^b ; Bei Xu^a ; Yan-Jie Xu^a ; Yong-Mei Yin^a ; ^{ym.yin@hotmail.com}
• 关键词：Breast cancer ; TNF-伪 ; CD44 ; Migration ; MAPK
• 刊名：Biomedicine and Pharmacotherapy
• 出版年：2012
• 期刊代码：36_07533322
• 类别：med
• 出版时间：March, 2012
• 卷：66
• 期：2
• 页码：144-150
• 文件大小：834 K

摘要

CD44 molecule plays critical role in distant malignant metastasis. It is expressed in standard form (CD44s) or variant form (CD44v). Tumor necrosis factor-伪 (TNF-伪) is highly expressed in the cancer microenvironment. TNF-伪 was reported to modulate CD44 expression in several kinds of cancer. However, little is known about pathological role of TNF-伪 in breast cancer (BC) cells. In the current investigation, we investigated the effect of TNF-伪 on BC cells (MCF-7 and MDA-MB-231) viability, CD44 expression, and in vitro migration. We found that TNF-伪 down-regulated CD44s expression, up-regulated CD44v3 and CD44v6 expression through JNK pathway in MCF-7 cells. In MDA-MB-231 cells, TNF-伪 up-regulated CD44s, CD44v3 and CD44v6 expression via p38 pathway. These data indicate important role of CD44 molecule in BC pathology.