Synthesis of phosphonomethoxyethyl or 1,3-bis(phosphonomethoxy)propan-2-yl lipophilic esters of acyclic nucleoside phosphonates

详细信息	查看全文 | 推荐本文 |

• 作者：Silvie Vrbková ; Martin Drač ; í ; nský ; ; Antoní ; n Holý
• 关键词：Acyclic nucleoside phosphonates (ANPs) ; PMEA ; PMEC ; PMEG ; Alkoxyalkyl phosphonates ; Hexadecyloxypropyl ester groups ; Bisphosphonates ; Synthesis
• 刊名：Tetrahedron
• 出版年：2007
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：12 November 2007
• 卷：63
• 期：46
• 页码：11391-11398
• 文件大小：250 K

摘要

A new alternative synthetic pathway towards mono and diesters of acyclic nucleoside phosphonates (PMEA, PMEC and PMEG) or [1,3-bis(phosphonomethoxy)propan-2-yl]adenine bearing one or two hexadecyloxypropyl ester groups (CH₂)₃O-n-C₁₆H₃₃ is reported.