Photodynamic efficacy of photosensitizers under an attenuated light dose via lipid nano-carrier-mediated nuclear targeting

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• 作者：Daishun Ling¹ ; Byoung-chan Bae¹ ; Wooram Park ; Kun Na ; ^{kna6997@catholic.ac.kr}
• 关键词：Nuclear targeting ; Nanostructured lipid carrier ; Photosensitizer ; Drug delivery ; Photodynamic therapy ; Deep-seated tumor
• 刊名：Biomaterials
• 出版年：2012
• 期刊代码：7_01429612
• 类别：ms
• 出版时间：July, 2012
• 卷：33
• 期：21
• 页码：5478-5486
• 文件大小：1424 K

摘要

Photodynamic therapy (PDT) has emerged as a treatment for certain malignant-like skin, head and neck, gastrointestinal, and gynecological cancers. The broader acceptance of PDT treatment for large or deep-seated tumors is still hindered, at least in part, by the low photodynamic efficiency of photosensitizers (PS) in the deep-seated tumor environment where the light energy fluency rate is severely attenuated after propagation via skin and/or tissue barriers. In this report, efficient nuclear-targeted intracellular delivery of PS is achieved using an easily fabricated yet entirely biocompatible and inexpensive polysaccharide-functionalized nanoscale lipid carrier, which triggers the intracellular release of photosensitizers inside cancer cells and targets cell nuclear to achieve a significantly enhanced photocytotoxicity. Cancer cells are killed efficiently even under an extremely low light fluency of 1聽mW/cm² attenuated via an interval meat layer with a thickness of 3聽mm. Therefore, this nuclei-targeting system may contribute to the development of a new generation of PS carriers that fight against deep-seated tumors and that exhibit excellent photodynamic efficiency under faint light irradiation.