mTHPC - A drug on its way from second to third generation photosensitizer?

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• 作者：Mathias O. Senge ; Dr. rer. nat. ; FTCD^a ; ^b ; ^{sengem@tcd.ie}
• 关键词：ALA ; 未-aminolevulinic acid ; Gly ; glycosyl ; HpD ; haematoporphyrin derivative ; mTHPC ; 5 ; 10 ; 15 ; 20-Tetrakis(3-hydroxyphenyl)chlorin ; mTHPP ; 5 ; 10 ; 15 ; 20-Tetrakis(3-hydroxyphenyl)porphyrin ; PD ; photodiagnostics ; PDT ; photodynamic therapy ; PS ; photosensitizer
• 刊名：Photodiagnosis and Photodynamic Therapy
• 出版年：2012
• 期刊代码：255_15721000
• 类别：med
• 出版时间：June, 2012
• 卷：9
• 期：2
• 页码：170-179
• 文件大小：511 K

摘要

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Summary

5,10,15,20-Tetrakis(3-hydroxyphenyl)chlorin (mTHPC, Temoporfin) is a widely investigated second generation photosensitizer. Its initial use in solution form (Foscan^庐) is now complemented by nanoformulations (Fospeg^庐, Foslip^庐) and new chemical derivatives related to the basic hydroxyphenylporphyrin framework. Advances in formulation, chemical modifications and targeting strategies open the way for third generation photosensitizers and give an illustrative example for the developmental process of new photoactive drugs.