Plastic components affect the activation of the aryl hydrocarbon and the androgen receptor

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• 作者：Tanja Krü ; ger ; Manhai Long ; Eva C. Bonefeld-Jø ; rgensen
• 关键词：Aryl hydrocarbon receptor ; Androgen receptor ; Mixtures ; Phenols ; Phthalates ; Reporter gene assay
• 刊名：Toxicology
• 出版年：2008
• 期刊代码：47_0300483x
• 类别：pha
• 出版时间：18 April 2008
• 卷：246
• 期：2-3
• 页码：112-123
• 文件大小：623 K

摘要

Phenols and plasticizers are widely used in the plastic industry, in food packaging and to impart softness and flexibility to normally rigid plastic medical devices and children's toys. The effects on the aryl hydrocarbon receptor (AhR) and the androgen receptor (AR) were assessed using luciferase reporter gene assays of the following compounds: bisphenol A (BPA), 4-n-nonylphenol (nNP), 4-tert-octylphenol (tOP), bis(2-ethylhexyl) phthalate (DEHP), di-isononyl phthalate (DINP), diisodecyl phthalate (DIDP), di-n-octyl phthalate (DNOP), dibutyl phthalate (DBP), benzyl butyl phthalate (BBP), 4-chloro-3-methylphenol (CMP), 2-phenylphenol (2-PP), 2,4-dichlorophenol (DCP), resorcinol and bis(2-ethylhexyl) adipate (DEHA). Furthermore, a mixture of selected compounds was tested at the no-observed-effect concentration (NOEC), the low-observed-effect concentration (LOEC) and the half-maximum-effect/inhibitory concentration (EC₅₀/IC₅₀) of the single chemicals.