Hepatoprotective and antioxidative effects of C-phycocyanin from Arthrospira聽maxima SAG 25780 in CCl₄-induced hepatic damage rats

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• 作者：S. Nagaraj^a ; ^{nagalilly@gmail.com} ; ^{nagus80@yahoo.com} ; P. Arulmurugan^a ; M.G. Rajaram^a ; K. Karuppasamy^b ; K.R. Jayappriyan^a ; R. Sundararaj^c ; N. Vijayanand^d ; R. Rengasamy^a
• 关键词：C-phycocyanin ; Histopathology ; Immunohistochemistry ; Carbon tetrachloride
• 刊名：Biomedicine & Preventive Nutrition
• 出版年：2012
• 期刊代码：pca73_22105239
• 类别：med
• 出版时间：April-June, 2012
• 卷：2
• 期：2
• 页码：81-85
• 文件大小：712 K

摘要

The efficacy of C-phycocyanin obtained from Arthrospira聽maxima SAG 25780 was evaluated on the levels of lipid peroxidation, and antioxidant parameters as well as histopathological and immunohistochemical assessment in carbon tetrachloride (CCl₄) induced liver damage in the male Wistar albino rats. The rats were injected by CCl₄ intraperitoneal (50%CCl₄, 0.5 mg/kg body weight) that led to a marked increase in oxidative stress indicated by alterations in lipid peroxidation, enzymic and non-enzymic antioxidants. Treatment with C-phycocyanin (75 mg/kg body weight) restored the above-mentioned alterations towards normalcy, highlighting the antioxidant potential of C-phycocyanin in mitigating the oxidative stress mediated damage produced during CCl₄-induced male rats. The liver damage was further confirmed by histopathological and immunohistochemical studies. The present investigation strongly suggested that the C-phycocyanin protects CCl₄-induced hepatotoxicity in Wistar rats.