Synthesis of 2,3,4,7-tetrahydro[1,4]thiazepines from thiazolidines and β-enaminonitriles

详细信息	查看全文 | 推荐本文 |

• 作者：Luis A. Calvo ; Alfonso Gonzá ; lez-Ortega ; Rocí ; o Marcos ; M&#xf3 ; nica Pé ; rez ; M. Carmen Sa&#xf1 ; udo
• 关键词：β ; -Enaminonitrile ; Tetrahydro[1 ; 4]thiazepine ; Thiazolidine
• 刊名：Tetrahedron
• 出版年：2008
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：21 April 2008
• 卷：64
• 期：17
• 页码：3691-3700
• 文件大小：530 K

摘要

A wide library of 2,3,4,7-tetrahydro[1,4]thiazepines have been prepared by simple heating of thiazolidine and β-enaminonitrile derivatives in acetonitrile. The procedure, whose yields depend on the nature and position of the substituents, gave good results if the substituents were not very bulky but it is less effective when starting from 2-substituted thiazolidines.