Chromium and genomic stability

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• 作者：Sandra S. Wise ; John Pierce Wise Sr. ; ^{John.Wise@maine.edu} ; ^{John.Wise@usm.maine.edu}
• 关键词：Chromium ; Chromate ; Trivalent chromium ; Hexavalent chromium ; Genomic instability
• 刊名：Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
• 出版年：2012
• 期刊代码：115_00275107
• 类别：bio
• 出版时间：1 May, 2012
• 卷：733
• 期：1-2
• 页码：78-82
• 文件大小：219 K

摘要

Many metals serve as micronutrients which protect against genomic instability. Chromium is most abundant in its trivalent and hexavalent forms. Trivalent chromium has historically been considered an essential element, though recent data indicate that while it can have pharmacological effects and value, it is not essential. There is no data indicating that trivalent chromium promotes genomic stability and, instead may promote genomic instability. Hexavalent chromium is widely accepted as highly toxic and carcinogenic with no nutritional value. Recent data indicate that it causes genomic instability and also has no role in promoting genomic stability.