Trigoxyphins H and I: Two new daphnane diterpenoids from Trigonostemon xyphophylloides

详细信息	查看全文 | 推荐本文 |

• 作者：Biao Yang^a ; ^b ; Guang-Ying Chen^a ; Xiao-Ping Song^a ; Liu-Qing Yang^d ; Chang-Ri Han^a ; ^{hchr116@hainnu.edu.cn} ; Xiang-Yang Wu^b ; ^c ; ^{wuxy@ujs.edu.cn} ; Xiao-Man Li^a ; Bing-Yan Zou^a
• 关键词：Trigonostemon ; Trigonostemon xyphophylloides ; Chemical constituents ; Cytotoxic activities
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：1 June, 2012
• 卷：22
• 期：11
• 页码：3828-3830
• 文件大小：415 K

摘要

Two new daphnane diterpenoids (1 and 2), together with four known analogues (3-6) were isolated from Trigonostemon xyphophylloides. Their structures were elucidated by spectroscopic analysis. Compounds 1 and 2 were evaluated for in vitro cytotoxic activities against the SPCA-1 (human lung cancer) and BEL-7402 (human hepatocellular carcinoma) cancer cell lines. Trigoxyphin I (2) showed modest cytotoxicity against two tumor cell lines.