Effect of butyrate on aromatase cytochrome P450 levels in HT29, DLD-1 and LoVo colon cancer cells

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• 作者：Agnieszka Anna Raw艂uszko^a ; Sylwia S艂awek^a ; Armin Gollogly^a ; Katarzyna Szkudelska^b ; Pawe艂 Piotr Jagodzi艅ski^a ; ^{pjagodzi@am.poznan.pl}
• 关键词：Aromatase ; Butyrate ; Colorectal cancer
• 刊名：Biomedicine and Pharmacotherapy
• 出版年：2012
• 期刊代码：36_07533322
• 类别：med
• 出版时间：March, 2012
• 卷：66
• 期：2
• 页码：77-82
• 文件大小：812 K

摘要

Epidemiological studies suggest that colonic production of butyrate and estrogen may be involved in human susceptibility to colorectal cancer (CRC). Estrone (E1) can be produced by the aromatase pathway during the conversion of androstenedione (A) to E1. Therefore, we studied the effect of sodium butyrate (NaBu) on the CYP19A1 transcript and protein levels and on the conversion of A to E1 in HT29, DLD-1 and LoVo CRC cells. We found that NaBu significantly downregulated CYP19A1 transcript and protein levels, a phenomenon that was associated with reduced conversion of A to E1 in HT29, DLD-1 and LoVo cells. Our studies demonstrated that, although butyrate exhibited a protective role in CRC development, this compound may reduce aromatase activity and the production of E1 in colon cancer cells.