Partial thyroid arterial embolization for the treatment of hyperthyroidism

详细信息	查看全文 | 推荐本文 |

• 作者：Krzysztof Brzozowski^a ; ^{k.brzoza@wp.pl} ; Piotr Piasecki^a ; Piotr Zi臋cina^a ; Emilia Frankowska^b ; Andrzej Jaroszuk^c ; Grzegorz Kami艅ski^c ; Romana Bogus艂awska-Walecka^b
• 关键词：Arterial embolization ; Thyroid ; Toxic nodular goiter ; Graves&rsquo ; disease
• 刊名：European Journal of Radiology
• 出版年：2012
• 期刊代码：93_0720048x
• 类别：med
• 出版时间：June, 2012
• 卷：81
• 期：6
• 页码：1192-1196
• 文件大小：837 K

摘要

ass="h4">Background

Hyperactive thyroid gland in patients that are unable to tolerate or accept standard therapy is a common clinical problem. Aim of the study was to evaluate effectiveness of partial thyroid arterial embolization in patients with hyperthyroidism.

ass="h4">Material/methods

From May 2004 to November 2005 partial thyroid gland embolization was performed in 15 patients. Mean thyroid gland volume was 162 ml. Embolization of one to three thyriod arteries was performed with the mixture of Histoacryl and Lipiodol. Selective angiography was performed after embolization to ensure that the targeted arteries were completely occluded. Follow-up study covered 12 patients.

ass="h4">Results

The embolization procedure was well tolerated by all patients. Three days after embolization fT3 and fT4 levels were higher than before the procedure. Further laboratory tests showed quick reversal to near-normal or normal levels of thyroid hormones. 12 weeks follow-up showed: normal serum levels of fT3, fT4 and TSH in 9 of 12 patients (75%), hyperthyroidism in 3 of 12 patients (25%), goiter volume reduction of approximately 32%of its original volume (from 13 to 76.3%), mean thyroid gland volume of 94 ml. One year after embolization 7 of 12 patients required thyreostatic drugs. At two and four years follow-up thyreostatics doses were significantly lower and thyroid tissue was fibrotic.

ass="h4">Conclusions

Based on our results the treatment of the thyroid gland goiters using arterial thyroid gland partial embolization may be offered as an effective alternative for patients who will not or cannot accept standard therapy.