A constitutively active ErbB4 mutant inhibits drug-resistant colony formation by the DU-145 and PC-3 human prostate tumor cell lines
- 作者：Williams ; Eric E. ; Trout ; Laurie J. ; Gallo ; Richard M. ; Pitfield ; Sarah E. ; Bryant ; Ianthe ; et. al.
- 关键词：ErbB4 ; Receptor tyrosine kinase ; Growth inhibition ; Tumor suppression ; Prostate cancer
- 刊名：Cancer Letters
- 出版年：2003
- 期刊代码：44_03043835
- 类别：med
- 出版时间：March 20, 2003
- 卷：192
- 期：1
- 页码：67-74
- 文件大小：380 K
摘要
ErbB4 (HER4) is a member of the ErbB family of receptor tyrosine kinases, a family that also includes the Epidermal Growth Factor Receptor (EGFR/ErbB1/HER1), Neu/ErbB2/HER2, and ErbB3/HER3. Several groups have hypothesized that signal transduction by the ErbB4 receptor tyrosine kinase is coupled to differentiation, growth arrest, and tumor suppression in mammary and prostate epithelial cells. In this report we demonstrate that a constitutively active ErbB4 mutant inhibits the formation of drug-resistant colonies by the DU-145 and PC-3 human prostate tumor cell lines. This is consistent with our hypothesis that ErbB4 signaling is growth inhibitory and may be coupled to tumor suppression in prostate cells.