Association between cocaine abuse in pregnancy and placenta-associated syndromes using propensity score matching approach

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• 作者：Alfred K. Mbah^a ; Amina P. Alio^a ; Doris W. Fombo^c ; Karen Bruder^b ; Getachew Dagne^a ; Hamisu M. Salihu^a ; ^b ; ^{hamisu.salihu@gmail.com}
• 关键词：Pregnancy ; Cocaine abuse ; Placenta-associated syndromes ; Propensity score matching
• 刊名：Early Human Development
• 出版年：2012
• 期刊代码：82_03783782
• 类别：med
• 出版时间：June, 2012
• 卷：88
• 期：6
• 页码：333-337
• 文件大小：263 K

摘要

Aims

We used propensity scores matching techniques to assess the association between maternal cocaine abuse in pregnancy and the occurrence of placenta-associated syndromes (PAS).

Study design

Mothers who abused cocaine (n = 5026) were matched to controls (n = 5026) from a sample of 1,693,197, unexposed mothers in Florida from 1998 to 2007. Cocaine abuse was identified using the ICD-9 principal and secondary diagnosis codes (304.2 for cocaine dependence and 305.6 for cocaine abuse). The outcome of interest, PAS, was identified as any indication in diagnosis field of ICD-9-CM codes for: placental abruption (641.2), oligohydramnios (658.0), placental infarction (656.7, 656.8, 656.9), gestational hypertension (642.3, 642.9), preeclampsia (642.4, 642.5, and 642.7) or eclampsia (642.6).

Results

Nearly 6%of mothers in the study sample experienced a condition associated with PAS prior to matching. Women who abused cocaine were 58%more likely to have PAS when compared to women who did not (OR = 1.48, 95%confidence interval: 1.33, 1.66). Women who abused cocaine were at elevated odds for placental abruption, placenta infarction and preeclampsia with the most pronounced odds noted for placental abruption (OR = 2.79, 95%confidence interval: 2.19, 3.55).

Conclusions

These findings indicate that cocaine abuse during pregnancy is associated with more placenta-related disorders than previously reported.