Effects of plasma nitric oxide levels on platelet activation in single donor apheresis and random donor concentrates
- 关键词：Platelet ; Platelet apheresis ; Platelet activation ; P-selectin ; Nitric oxide
- 刊名：Transfusion and Apheresis Science
- 出版年：2007
- 期刊代码：248_14730502
- 类别：med
- 出版时间：February 2007
- 卷：36
- 期：1
- 页码：73-78
- 文件大小：254 K
摘要
P-selectin is an useful marker to determine platelet activation and nitric oxide inhibits platelet activation, secretion, adhesion and aggregation. The aim of this study was to investigate the relationship between nitric oxide and P-selectin values in both single donor apheresis and random donor platelet concentrates. According to the results of this study, we found that the best platelet concentrate is freshly prepared single donor apheresis concentrate and it is important to prevent activation at the beginning of the donation. Nitric oxide, which is synthesized from platelets during the storage period, is not sufficient to prevent platelet activation.