Role of phospholipase C蔚 in physiological phosphoinositide signaling networks

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• 作者：Alan V. Smrcka^a ; ^b ; ^c ; ^{Alan_Smrcka@urmc.rochester.edu} ; Joan Heller Brown^d ; ^{jhbrown@ucsd.edu} ; George G. Holz^e ; ^{holzg@upstate.edu}
• 关键词：PLC ; phosphoinositide-specific phospholipase C ; PKC ; protein kinase C ; LPA ; lysophosphatidic acid ; S1P ; sphingosine-1 phosphate ; Epac ; Exchange protein directly activated by cAMP ; GPCR ; G protein-coupled receptor ; GEF ; guanine nucleotide exchange factor
• 刊名：Cellular Signalling
• 出版年：2012
• 期刊代码：42_08986568
• 类别：bio
• 出版时间：June, 2012
• 卷：24
• 期：6
• 页码：1333-1343
• 文件大小：610 K

摘要

Receptor-initiated phospholipase C activation and generation of IP₃ and DAG are important common triggers for a diversity of signal transduction processes in many cell types. Contributing to this diversity is the existence and differential cellular and subcellular distribution of distinct phospholipase C isoforms with distinct regulatory properties. The recently identified PLC蔚 enzyme is an isoform that is uniquely regulated by multiple upstream signals including ras-family GTP binding proteins as well as heterotrimeric G-proteins. In this review we will consider the well documented biochemical regulation of this isoform in the context of cell and whole animal physiology and in the context of other G protein-regulated PLC isoforms. These studies together reveal a surprisingly wide range of unexpected functions for PLC蔚 in cellular signaling, physiology and disease.