Poly(l-glutamic acid)-based star-block copolymers as pH-responsive nanocarriers for cationic drugs

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• 作者：Huihong Huang ; Jiayan Li ; Lihui Liao ; Jinhu Li ; Lixin Wu ; Chaoke Dong ; Peibao Lai ; Daojun Liu ; ^{liudj@stu.edu.cn}
• 关键词：Poly(l-glutamic acid) ; Star-block copolymer ; Drug delivery system ; pH-responsive
• 刊名：European Polymer Journal
• 出版年：2012
• 期刊代码：35_00143057
• 类别：ms
• 出版时间：April, 2012
• 卷：48
• 期：4
• 页码：696-704
• 文件大小：836 K

摘要

Star-block copolymers PEI-g-(PLG-b-PEG), which consist of a hyperbranched polyethylenimine (PEI) core, a poly(l-glutamic acid) (PLG) inner shell, and a poly(ethylene glycol) (PEG) outer shell, were synthesised and evaluated as nanocarriers for cationic drugs. The synthesised star-block copolymers were characterised by ¹H NMR, gel permeation chromatography (GPC), dynamic light scattering (DLS), and transmission electron microscopy (TEM). Crystal violet (CV), as a model cationic dye, and doxorubicin hydrochloride (DOX), as a model anticancer drug, could be efficiently entrapped by the synthesised star-block copolymers at physiological pH as a result of electrostatic interactions between the cationic guest molecules and the negatively charged PLG segments in the PEI-g-(PLG-b-PEG) host. The drug-polymer complexes showed relatively high temporal stability at physiological pH and sustained release of the encapsulated drugs was observed. The entrapped model compounds demonstrated accelerated release as the pH was gradually decreased.