Poly(l-aspartic acid) derivative soluble in a volatile organic solvent for biomedical application

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• 作者：Nam Muk Oh^a ; Kyung Taek Oh^b ; Yu Seok Youn^c ; Eun Seong Lee^a ; ^{hejulu@hanmail.net} ; ^{eslee@catholic.ac.kr}
• 关键词：Poly(l-aspartic acid) derivative ; Diethylaminopropyl group ; Volatile solvent ; pH-sensitive polymer
• 刊名：Colloids and Surfaces B ; Biointerfaces
• 出版年：2012
• 期刊代码：14_09277765
• 类别：ms
• 出版时间：1 September, 2012
• 卷：97
• 期：Complete
• 页码：190-195
• 文件大小：710 K

摘要

In order to develop a novel functional poly(l-amino acid) that can dissolve in volatile organic solvents, we prepared poly[l-aspartic acid-g-(3-diethylaminopropyl)]-b-poly(ethylene glycol) [poly(l-Asp-g-DEAP)-b-PEG] via the conjugation of 3-diethylaminopropyl (DEAP) to carboxylate groups of poly(l-Asp) (M_n 4 K)-b-PEG (M_n 2 K). This poly(l-aspartic acid) derivative evidenced a relatively high solubility in volatile organic solvents such as dichloromethane, chloroform, and acetone. We fabricated a model nanostructure (i.e., polymeric micelle) using poly(l-Asp-g-DEAP)-b-PEG by the film rehydration method, which involves the simple removal of the volatile organic solvent (dichloromethane) used to dissolve polymer, reducing concerns about organic solvents remaining in a nano-sized particle. Interestingly, this micelle showed the pH-stimulated release of encapsulated model drug [i.e., doxorubicin (DOX)] due to the protonation of DEAP according to the pH of the solution. We expect that this poly(l-aspartic acid) derivative promises to provide pharmaceutical potential for constituting a new stimuli-sensitive drug carrier for various drug molecules.